Any unusual appearing penile lesion should be examined by a urologist. Fortunately, penile cancer is quite rare in the United States. However, when present it can be aggressive. There are a number of different treatments for penile cancer including excision, laser, and total or partial amputation of the penis (penectomy). Radiation is occasionally utilized as well. Advanced cases of penile cancer may later require surgical removal of the inguinal (groin) lymph nodes.